RESEARCH LIBRARY

Research and indications OF CURCUMIN

Turmeric has been traditionally used for thousands of years in Ayurvedic and Chinese medicine and is used commonly in cooking.

The bioactive compound in Curcuma longa (Turmeric) extract is curcumin. Curcumin is a polyphenol with anti-inflammatory actions in the body. 

To feel the potent health benefits of curcumin, it is extracted and concentrated from the turmeric root. The natural bioavailability of curcumin is poor, but upon combination with piperine, the bioavailability is increased and you absorb it better in the gut.

1. reduces mild joint pain and symptoms of mild arthritis/ osteoarthitis

A systematic review of ten studies was conducted by Paultre and colleagues (2021). to determine the effects of curcumin on pain and function for individuals with knee osteoarthritis.

The key finding was that all ten studies showed significant improvement in osteoarthritis pain and function.

Another systematic review by Liu and colleagues (2018) were investigating dietary supplements for osteoarthritis. 

They concluded that curcumin had clinically meaningful effects when taken for osteoarthritis for reduction in pain and function.

  1. Paultre, K., et al. 2021. Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review. BMJ open sport & exercise medicine7 (1), e000935.
  2. Liu, X., et al. 2018. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. British journal of sports medicine52 (3), 167–175.

2. Anti-inflammatory

Curcumin has been shown to have a similar anti-inflammatory level as non-steroidal anti-inflammatories (NSAIDs).

The anti-inflammatory molecules curcumin influences NF kappa Beta activity by interacting or inhibiting  interleukins, phospholipase A2, 5-lipoxygenase enzyme and COX-2.

  1. Paultre, K., et al. 2021. Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review. BMJ open sport & exercise medicine(1), e000935.
  2.  Liu, X., et al. 2018. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. British journal of sports medicine52 (3), 167–175.

3. relieves pain (analgesic)

The systematic review by Paultre and colleagues were testing the effect of curcumin on pain associated with knee osteoarthritis compared to classic NSAID anti-inflammatories. The systematic review found that in all 10 studies, there was a significant reduction in pain compared to the placebo. When they compared it to the NSAID group, the reduction of pain was equal. They concluded curcumin therapy may be an attractive replacement for people who cannot take NSAIDs anymore due to their ability to damage stomach lining.

Another systematic review revealed curcuma longa extract has a statistically significant difference in analgesic (pain relieving) ability in the short term.

  1. Paultre, K., et al. 2021. Therapeutic effects of turmeric or curcumin extract on pain and function for individuals with knee osteoarthritis: a systematic review. BMJ open sport & exercise medicine(1), e000935.
  2. Liu, X., et al. 2018. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. British journal of sports medicine52 (3), 167–175.

4. antioxidant

The curcumin molecule has functional antioxidant groups including a diketone, a phenol ring and carbon carbon double bonds. 

Research has shown the molecule is able to inhibit lipid peroxidation and reactive oxygen species (ROS) and reactive nitrogen species (RNS) responsible for free-radical damage in our bodies.

Research conducted by DiSilvio and colleagues tested free-radical scavenging capacity of the saliva and showed that it in fact increased, meaning that curcumin is able to directly have an antioxidant effect. They also found that curcumin indirectly has antioxidant effects by elevated plasma activities of the enzyme antioxidant catalase.

  1. Farzaei, M., Zobeiri, M., Parvizi, F., El-Senduny, F., Marmouzi, I., Coy-Barrera, E., Naseri, R., Nabavi, S., Rahimi, R., and Abdollahi, M. (2018) Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective. Nutrients 10, 855.
  2. DiSilvestro, R., Joseph, E., Zhao, S., and Bomser, J. (2012) Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal 11.

5. supports healthy cholesterol and blood lipids

A systematic review by Farzaei and colleagues found that supplementation with curcumin (500 mg a day) reduced total cholesterol and LDL (bad cholesterol) and increased HDL (good cholesterol).

A study conducted on healthy middle aged male and females suppemented with 80 mg of curcumin a day found that plasma triglycerides (blood lipids) were reduced compared to the placebo.

  1. Farzaei, M., Zobeiri, M., Parvizi, F., El-Senduny, F., Marmouzi, I., Coy-Barrera, E., Naseri, R., Nabavi, S., Rahimi, R., and Abdollahi, M. (2018) Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective. Nutrients 10, 855.
  2. DiSilvestro, R., Joseph, E., Zhao, S., and Bomser, J. (2012) Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal 11.

6. Supports liver health & protects the liver (hepatoprotectant)

Th systematic review in 2018 on supplementation of curcumin in liver disease concluded that curcumin was able to support liver health and able to protect the liver. They reveal a number of biochemical pathways it does protect the liver, but the main pathways are reducing oxidative damage in the liver.

The study by DiSilvestro and colleagues found that the marker for liver injury, ALT, was reduced after supplementation of 80 mg of curcumin a day. They concluded this dosage was promising to help maintain liver health.

  1. Farzaei, M., Zobeiri, M., Parvizi, F., El-Senduny, F., Marmouzi, I., Coy-Barrera, E., Naseri, R., Nabavi, S., Rahimi, R., and Abdollahi, M. (2018) Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective. Nutrients 10, 855.
  2. DiSilvestro, R., Joseph, E., Zhao, S., and Bomser, J. (2012) Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutrition Journal 11.

7. relieves symptoms of indigestion

Current evidence from the meta-analysis by Ng and colleagues suggests that curcumin has a positive albeit not statistically significant effect (compared to placebo) on Irritable Bowel Syndrome (IBS) symptoms.

Curcumin is able to relieve symptoms of indigestion by reducing pain and inflammation in the gut. People with poor gut health tend to have a lot of inflammation, making indigestion worse.

  1. Ng, Q., Soh, A., Loke, W., Venkatanarayanan, N., Lim, D., and Yeo, W. (2018) A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS). Journal of Clinical Medicine 7, 298.

8. helps improve the body’s metabolism

A systematic review and meta-analysis of randomized controlled trials was conducted by Akbari in 2019 to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders.

Administered curcumin in trials included in the present meta-analysis was as powder, or extract. 18 articles (21 trials) were determined to be appropriate for in the  meta-analysis. They demonstrated that curcumin intake significantly decreased BMI, weight, waist circumference, and leptin, and significantly increased adiponectin levels.

They concluded that these changed were due to inhibiting a number of biochemical pathways that promote adipose tissue storage, but rather increase the metabolism of fat.

  1. Akbari, M., Lankarani, K., Tabrizi, R., Ghayour-Mobarhan, M., Peymani, P., Ferns, G., Ghaderi, A., and Asemi, Z. (2019) The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in Pharmacology 10.

Research and indications OF BOSWELLIA sERRATA (bOSWELLIC ACIDS)

Boswellia serrata, otherwise known as Indian Frankincense, is a tree found in India, North Africa and the Middle East. It was traditionally used for its nice smell in incense. 

It has also been used in traditional Ayurvedic medicine to treat inflammation and stomach issues. 

The active ingredients in Boswellia serrata are found in the gum resin and are called boswellic acids.

1. reduces mild joint pain and symptoms of mild arthritis/ osteoarthitis

A systematic review by Liu and colleagues (2018) were investigating dietary supplements for osteoarthritis. 

They concluded that Boswellia had clinically meaningful effects when taken for osteoarthritis for reduction in pain and function.

Majeed and colleagues conducted a randomised double-blind placebo to test the efficacy of Boswellia on management of knee osteoarthristis. They concluded from the 48 patients who took boswellia for 120 days that the anti-inflammatory and anti-arthritic effect reduced pain  and improved physical function.

  1. Liu, X., et al. 2018. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. British journal of sports medicine52 (3), 167–175.
  2. Majeed, M., Majeed, S., Narayanan, N., and Nagabhushanam, K. (2019) A pilot, randomized, double‐blind, placebo‐controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytotherapy Research 33, 1457-1468.All the authors are affiliated to Sami Labs Limited or Sabinsa Corpora-tion. Sabinsa Corporation and Sami Labs hold patents/trademarks cov-ering Boswellin®.

2. Anti-inflammatory

Boswellia contains the bioactive compounds boswellic acids. The strongest compound is called 3-O-Acetyl-11-keto-beta-boswellic acid (AKBA). This molecule has been shown to have anti-inflammatory properties by inhibiting 5-lipoxygenase (5-LOX). 5-LOX is a well-known pro-inflammatory cytokine. 

  1. Liu, X., et al. 2018. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. British journal of sports medicine52 (3), 167–175.
  2. Yu, G., Xiang, W., Zhang, T., Zeng, L., Yang, K., and Li, J. (2020) Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complementary Medicine and Therapies 20.

3. relieves pain

From the same papers as indication one, it was shown that taking Boswellia serrata daily, it could reduce pain related to osteoarthritis at a similar level to over the counter NSAID anti-inflammatories.

  1. Liu, X., et al. 2018. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. British journal of sports medicine52 (3), 167–175.
  2. Majeed, M., Majeed, S., Narayanan, N., and Nagabhushanam, K. (2019) A pilot, randomized, double‐blind, placebo‐controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytotherapy Research 33, 1457-1468.All the authors are affiliated to Sami Labs Limited or Sabinsa Corpora-tion. Sabinsa Corporation and Sami Labs hold patents/trademarks cov-ering Boswellin®.

4. helps maintain a healthy blood sugar level

A review completed by Mahdian and colleagues on how Boswellia can help individuals with metabolic syndrome find some interesting results. In particular they found that Boswellia species reduce the resistance to insulin, restoring pancreatic beta cells. This is turn decreases blood glucose to healthy levels. It should be noted this study was conducted in unhealthy individuals, but may still play a role at maintaining healthy blood sugar levels in healthy individuals.

  1. Mahdian D., Abbaszadeh-Goudarzi K., Raoofi A., Dadashizadeh G., Abroudi M., Zarepour E., Hosseinzadeh H. (2020) Effect of Boswellia species on metabolic syndrome: A review. Iranian Journal of Basic Medical Sciences, 23, 1374-1381.

5. helps improve metabolism

The same review as indication four reveals that Boswellia species s able to control hyperglycemia, dyslipidemia, hypertension,
obesity, diabetes, and its complications. 

  1. Mahdian D., Abbaszadeh-Goudarzi K., Raoofi A., Dadashizadeh G., Abroudi M., Zarepour E., Hosseinzadeh H. (2020) Effect of Boswellia species on metabolic syndrome: A review. Iranian Journal of Basic Medical Sciences, 23, 1374-1381.

6. supports liver health and protects the liver

In this paper the authors reveal that in type 2 diabetics, taking Boswellia for 6 weeks causes a reduction in SGPT and SGOT (otherwise known as ALT).  Boswellia possess partial  hepatoprotective effect. This was also backed up by Pandey et al. who reported that Boswellia serrata oleo gum is able to decrease the production of nitric oxide (NO). Reduction of NO in the liver tissue results in liver protective effects.

  1. Ahangarpour, A., Heidari, H., Fatemeh, R., Pakmehr, M., Shahbazian, H., Ahmadi, I., Mombeini, Z., and Mehrangiz, B. (2014) Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients. Journal of Diabetes & Metabolic Disorders 13.

7. relieves symptoms of medically diagnosed irritable bowel syndrom (IBS)

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  1. Gupta, I., Parihar, A., Malhotra, P., Gupta, S., Lüdtke, R., Safayhi, H., and Ammon, H. (2001) Effects of Gum Resin of Boswellia serrata in Patients with Chronic Colitis. Planta Medica 67, 391-395.

8. relieves symptoms of indigestion

In conclusion, this study shows that a gum resin preparation from Boswellia serrata could be effective in the treatment of chronic colitis with minimal side effects.

  1. Gupta, I., Parihar, A., Malhotra, P., Gupta, S., Lüdtke, R., Safayhi, H., and Ammon, H. (2001) Effects of Gum Resin of Boswellia serrata in Patients with Chronic Colitis. Planta Medica 67, 391-395.

9. supports immune system health

Boswellic acids modulate the immune system by altering cytokine activity. BAs inhibit NFB, consequently a down regulation of TNF- and decrease of  proinflammatory cytokines by BAs.

BAs have a variety of different actions in the immune system. Depending on the dose they may be stimulating in lower doses or inhibitory in higher doses.

  1. Ammon, H. (2010) Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Phytomedicine 17, 862-867.

10. Maintains a healthy cholesterol and blood lipid level

A study conducted by Ahagarpour et al. (2014) was supplementing type 2 diabetic patients with 3 x 300 mg of Boswellia for 6 weeks. They took blood work and results revealed a significant increase in blood HDL levels and a decrease in cholesterol & LDL after 6 weeks.

  1. Ahangarpour, A., Heidari, H., Fatemeh, R., Pakmehr, M., Shahbazian, H., Ahmadi, I., Mombeini, Z., and Mehrangiz, B. (2014) Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients. Journal of Diabetes & Metabolic Disorders 13.

Research and indications OF PROCYANIDINS

Grape seed extract contains the bioactive compounds called procyanidins which is a combination of the molecules catechin and epicatchin. They contain antioxidant activity.

Procyanidins have been found to act as a linker between the collagen matrix, which is why it has benefits to skin health.

1. ANTIOXIDANT

Procyanidins are made up of polyphenols which are known antioxidants. Grape seeds have high antioxidant effects; their benefits include modulation of antioxidant enzyme expression, protection against oxidative damage in cells, anti-atherosclerotic and anti-inflammatory effects.

Foshati, S., Rouhani, M., and Amani, R. (2021) The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta‐analysis of controlled trials. International Journal of Clinical Practice 75.

2. SUPPORTS COLLAGEN HEALTH

Procyanidins are known to be collagen cross-linkers. They also inhibit the breakdown of collagen, keeping the skin elastic. This slows the ageing process of the skin.

  1. (11) Sochorova, L., Prusova, B., Cebova, M., Jurikova, T., Mlcek, J., Adamkova, A., Nedomova, S., Baron, M., and Sochor, J. (2020) Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical MarkersMolecules 25, 5311.

3. HELPS PREVENT SKIN ELASTIN FROM BREAKING DOWN

Skin elastin is dependant on collagen health. procyanidins prevent the breakdown of collagen, which keeps the skin nice and plump.

  1. (11) Sochorova, L., Prusova, B., Cebova, M., Jurikova, T., Mlcek, J., Adamkova, A., Nedomova, S., Baron, M., and Sochor, J. (2020) Health Effects of Grape Seed and Skin Extracts and Their Influence on Biochemical MarkersMolecules 25, 5311.

4. RELIEVES SYMPTOMS OF MILD ANXIETY

Some new and emerging research on mild anxiety and stress was completed in 2021. The study found an improved perception of mood after supplementation of 300 mg a day.

This was supported by another study that found GSE supplementation improved mild anxiety in menopausal women.

  1. (10) Schön, C., Allegrini, P., Engelhart-Jentzsch, K., Riva, A., and Petrangolini, G. (2021) Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers. Nutrients 13, 654.

5. RELIEVES SYMPTOMS OF STRESS

A study found a statistically significant reduction in worry and an improvement in perceived stress after GSE supplementation.

  1. (10) Schön, C., Allegrini, P., Engelhart-Jentzsch, K., Riva, A., and Petrangolini, G. (2021) Grape Seed Extract Positively Modulates Blood Pressure and Perceived Stress: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Volunteers. Nutrients 13, 654.

Research and indications OF ASHWAGANDHA

1. DECREASES SYMTPOMS OF MILD ANXIETY

A double-blind, placebo-controlled study carried out by Andrade et al. to evaluate the the effect of Aswagandha (Withania somnifera), in patients with anxiety disorders. The authors concluded that ashwagandha has anxiolytic potential.

Since this paper in 2000, Ashwagandha has had a lot of attention and much more research has been carried out to confirm this effect.

  1. Andrade, C., Aswath, A., Chaturvedi, S. K., Srinivasa, M., Raguram, R., A double-blind, placebo-controlled evaluation of the anxiolytic efficacy ff an ethanolic extract of withania somnifera. Indian J Psychiatry 2000, 42 (3), 295-301.

  2. Salve, J.; Pate, S.; Debnath, K.; Langade, D., Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus 2019, 11 (12), e6466.

2. ENHANCES THE BODY’S ADAPTION TO STRESS

A Randomised double blind placebo controlled trial by Chandrasekhar and colleagues (2012) testing the ability of ashwagandha to reduce stress and anxiety.

64 subjects were given 300 mg of full-spectrum ashwagandha extract (5% withanolides) a day. 

The results showed a reduction in all stress assessment tests. This was also supported by the bloodwork where serum cortisol levels were reduced compared to the control group.

Their conclusion was that ashwaganhda had the ability to improve the body’s resistance to stress, in turn improving self-assessed quality of life.

  1. Chandrasekhar K, Kapoor J, Anishetty S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety
    and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 34, 255-62.
  2. Salve, J.; Pate, S.; Debnath, K.; Langade, D., Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus 2019, 11 (12), e6466.
  3.  

3. DECREASES SYMTPOMS OF STRESS

Similar to above.

  1. Chandrasekhar K, Kapoor J, Anishetty S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety
    and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 34, 255-62.

4. ENHANCES PHYSICAL STAMINA AND ENDURANCE

Maximum oxygen consumption (VO2max) is an indicator of the the aerobic capacity of an individual. It gives us an idea of  the fitness of an individual. A systematic review on Ashwagandha was conducted to test if VO2 max was affected after supplementation. 

Results showed a significant enhancement in VO2max in healthy adults and athletes suggesting that supplementation would increase stamina and endurance while exercising.

  1.  Pérez-Gómez, J., Villafaina, S., Adsuar, J., Merellano-Navarro, E., and Collado-Mateo, D. (2020) Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis. Nutrients 12, 1119.

5. ENHANCES ENERGY LEVELS

Ashwagandha enhances energy levels through the mechanism above by increasing VO2 max.

Another paper by Lopresti et al. completed a study on effects of ashwagandha on hormones and vitality in aging and overweight males. They found that there was an improvement in fatigue, vigour, and sexual and psychological well-being were reported over time.

 

  1. Pérez-Gómez, J., Villafaina, S., Adsuar, J., Merellano-Navarro, E., and Collado-Mateo, D. (2020) Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis. Nutrients 12, 1119.
  2. Lopresti, A. L.; Drummond, P. D.; Smith, S. J., (2019). A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males. Am J Mens Health, 13 (2), 1557988319835985.

6. SUPPORTS BRAIN HEALTH

A study conducted by Ng and colleagues tested Ashwagandha’s ability to prevent brain function decline in people with degenerative disorders. They concluded there were cognitive benefits to prevent early mental decline

  1. Ng, Q., Loke, W., Foo, N., Tan, W., Chan, H., Lim, D., and Yeo, W. (2019) A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction. Phytotherapy Research 34, 583-590.

7. SUPPORTS FOCUS, CONCENTRATION AND CLARITY

The same paper as above, also revealed interesting results including the following: improved performance on cognitive tasks, executive function, attention, and reaction time. This evidence suggests that Ashwagandha also has beneficial effects in healthy individuals for cognitive health.

  1. Ng, Q., Loke, W., Foo, N., Tan, W., Chan, H., Lim, D., and Yeo, W. (2019) A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction. Phytotherapy Research 34, 583-590.

8. TRADITIONALLY USED IN AYURVEDIC MEDICINE TO ENHANCE SLEEP QUALITY

Traditional use of Ashwagandha shows improved sleep quality, length and deep sleep.

Traditional evidence:

Ashwagandha – Monograph (Health Canada)

9. HELPS MAINTAIN A HEALTHY BLOOD SUGAR LEVEL

Hypoglycemic, diuretic and hypocholesterolemic effects of roots of ashwagandha were assessed for 30 days by Andallu and colleagues.

They concluded that Ashwagandha had hypoglycaemic effects.

Andallu, B.; Radhika, B., Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian J Exp Biol 2000, 38 (6), 607-9.

Research and indications OF RESVERATROL

1. ANTIOXIDANT

A study by Espinoza and colleagues found that resveratrol supplementation showed there was an increase in overall antioxidant capacity in blood samples. This is in agreement that polyphenol molecules has antioxidant capacity.

  1. Espinoza, J. L.; Trung, L. Q.; Inaoka, P. T.; Yamada, K.; An, D. T.; Mizuno, S.; Nakao, S.; Takami, A.. (2017) The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans. Oxid Med Cell Longev, 2017, 6781872.

2. HELPS IMPROVE METABOLISM

Data shows that like calorie restriction, resveratrol supplementation lowers energy expenditure, improves metabolic profile, as well as global health parameters.

  1. Timmers, S.; Konings, E.; Bilet, L.; Houtkooper, R. H.; van de Weijer, T.; Goossens, G. H.; Hoeks, J.; van der Krieken, S.; Ryu, D.; Kersten, S.; Moonen-Kornips, E.; Hesselink, M. K. C.; Kunz, I.; Schrauwen-Hinderling, V. B.; Blaak, E.; Auwerx, J.; Schrauwen, P., Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011, 14 (5), 612-22.

3. HELPS SUPPORT HEALTHY BLOOD SUGAR LEVELS

After the fourth week, resveratrol significantly decreased insulin resistance (homeostasis model of assessment for insulin resistance) and urinary ortho-tyrosine excretion, while it increased the pAkt:Akt ratio in platelets.

  1. Brasnyo, P.; Molnar, G. A.; Mohas, M.; Marko, L.; Laczy, B.; Cseh, J.; Mikolas, E.; Szijarto, I. A.; Merei, A.; Halmai, R.; Meszaros, L. G.; Sumegi, B.; Wittmann, I., Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr 2011, 106 (3), 383-9.

4. SUPPORTS CARDIOVASCULAR SYSTEM HEALTH

results from a study performed my Magyar in 2012, showed that resveratrol improved left ventricle diastolic function, endothelial function, lowered LDL-cholesterol level and protected against unfavourable hemorheological changes measured in patients with coronary artery disease. These finding suggest resveratrol has cerdio protective properties.

  1. Magyar, K., Halmosi, R., Palfi, A., Feher, G., Czopf, L., Fulop, A., Battyany, I., Sumegi, B., Toth, K., and Szabados, E. (2012) Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery diseaseClinical Hemorheology and Microcirculation 50, 179-187.

5. ENHANCES HEALTHY BLOOD CIRCULATION

  1. Magyar, K., Halmosi, R., Palfi, A., Feher, G., Czopf, L., Fulop, A., Battyany, I., Sumegi, B., Toth, K., and Szabados, E. (2012) Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery diseaseClinical Hemorheology and Microcirculation 50, 179-187.
  2. Wightman, E. L.; Reay, J. L.; Haskell, C. F.; Williamson, G.; Dew, T. P.; Kennedy, D. O., (2014 Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr, 112 (2), 203-13.

6. SUPPORTS BONE HEALTH

A paper studying post-menopausal women’s bone density after supplementation with resveratrol showed positive effects. after 12 months, bone density increased, especially in the lumbar spine and neck.

Wong, R. H.; Thaung Zaw, J. J.; Xian, C. J.; Howe, P. R.. (2020) Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. J Bone Miner Res, 35 (11), 2121-2131.

Piperine has emerging health benefits but clinical research is still in the early stages.

The purpose of piperine in our formulation is to naturally increase bioavailability.

Bioavailability is a measure of how well a molecule will absorb in the gut, how long it will stay in the blood stream and how much of the molecule will be absorbed by tissues to exert its active effect.

Piperine works by inhibiting an enzyme that metabolises curcumin and resveratrol. This allows it to stay in the blood and tissues for longer before being excreted by the body.